Corruption in healthcare sector could have severe consequences for access, quality, equity, efficiency, and efficacy of health services. Different measures could be obtained in regard to prevention and control of informal payments and corruption practices in the healthcare sector. Most of the measures are targeted at patients, medical professionals, and/or health care institutions. To improve the basis for more sustainable and efficient healthcare system there has to be implementation of strong and effective mechanisms for control and reduce of corruption practices involving all stakeholders. Successful action against prevention and limitation of corruption depends on knowledge-based attitude. Corruption could be limited or prevented when there are no gaps in legal regulatory framework, in the structure of the regulations themselves, as well as in monitoring and enforcement mechanisms applied.