Healthcare systems are highly vulnerable to exposure to corruption risk, as this is being observed especially in times when high pressure is being applied on the healthcare sector. In times of emergency situations such involving high public health risks, the healthcare systems are functioning under conditions requiring the involvement of protective mechanisms against bribery in medical related services, public procurement and fraud. Corruption risks in the healthcare sector could apply to national, central or local levels as such risks could involve different types of medical facilities, hospitals or medicalized structures. They could directly involve or be related to access to healthcare and treatment or access to specific medical product or vaccine. Many national legislations have adopted regulations for facilitating national procurement laws allowing public buyers to purchase medical and personal protective equipment faster and easier avoiding heavy administrative procedures. Policymakers developing regulation in procurement system must balance a number of goals. Measures to restrict negative results from corruption practices or even to eliminate corruption activities could involve corruption risk assessment, identifying and protecting vulnerable individuals and communities, as well as introducing transparent and accountable public procurement processes.